Past Conferences

 
 
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RUNX1 SANTA BARBARA 2018
2ND ANNUAL SCIENTIFIC MEETING
SANTA BARBARA, CALIFORNIA NOV 4-6, 2018

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Organizers: The Babich Family, Nancy A. Speck, Ph.D. and Paul Liu, M.D., Ph.D.

The RUNX1 Research Program hosted our second annual RUNX1 2018 Meeting and Retreat in Santa Barbara, California, at the historic Four Seasons, Biltmore Resort.

All ten recipients of RRP’s two current grant programs (in partnership with Alex’s Lemonade Stand Foundation for Childhood Cancer and the Leukemia & Lymphoma Society) presented on the progress and state of their RUNX1 research. There were also presentations by the investigators of two special-project grants we have funded, under the determination that they were critical for general advancement of the field.

Several thought leaders on clonal hematopoiesis shared presentations, and specialists in hereditary leukemia spoke on clinical and genomic observations of families with multiple generations of RUNX1-FPD.

Dr. Paul Liu, Director of the National Institutes of Health RUNX1-FPD Clinical Research Study, presented on the groundbreaking new NIH natural history study that launched in May 2019 and will provide a foundation for future research in the field. A number of attendants and key leaders in the clinic from both the NIH and NCI were present at the Meeting.

PROGRAM

Four Seasons, The Biltmore Resort
1260 Channel Drive, Santa Barbara, California 93108

Sunday, November 4 – La Marina Room

  • 17:00 – 18:00 Registration

  • 18:00 – 19:30 Dinner. Opening remarks and State of the RUNX1 Research Program, Tim Babich, Nancy Speck, Monica Babich, and Katrin Ericson

  • 19:30 – 19:50 Anna Brown (University of S. Australia), FPD/AML RUNX1 Mutation Database

  • 19:50 – 20:10 Paul Liu (NIH), NIH RUNX1-FPD Center & Study

  • 20:10 – 20:30 Nicolas Duployez, (Centre Hospitalier Régional Universitaire de Lille), Somatic Mutations Associated with Leukemic Progression of FPD/AML

  • 20:30 – 22:00 Cocktails and Dessert

Monday, November 5 – Loggia Terrace

  • 6:45 – 7:45 Sunrise Ocean-View Guided Walk by a Santa Barbara Local

  • 8:00 – 9:00 Breakfast

Session 1. – Las Flores/El Presidente Rooms

  • 9:00 – 9:10 Paul Liu (NIH), Chair

  • 9:10 – 9:30 Len Zon (Boston Children’s Hospital), Modeling RUNX1-associated Clonal Hematopoietic Disorders in Zebrafish

  • 9:30 – 9:50 Ravi Majeti (Stanford), Characterization of Pre-Leukemia Associated with Familial RUNX1 Mutations

  • 9:50 – 10:10 Nancy Speck (Penn), Mouse Models of Secondary Mutations in FPD/AML

  • 10:10 – 10:30 Zuzana Tothova (Dana Farber Cancer Institute), The Role of STAG2 and RUNX1 in Myeloid Malignancies

  • 10:30 – 11:00 Coffee Break

  • 11:00 – 11:20 Eirini Papapetrou (Icahn/Mt Sinai), Identifying Therapeutic Targets to Prevent Progression of Familial RUNX1 Disorder to AML using Novel iPSC Models

  • 11:20 – 11:40 Mortimer Poncz (CHOP), Drug Screen for FPD/AML Therapeutic

  • 11:40 – 12:00 Anupriya Agarwal (OHSU), Role of Inflammatory Microenvironment in Clonal Evolution and Progression from FPD to AML

  • 12:00 – 13:30 Lunch – Palmera Garden

  • 13:30 – 13:50 Guy Sauvageau (Institute for Research in Immunology and Cancer, Université de Montréal, Canada), Genetic Screening of Drug Sensitivity for RUNX1 AML

  • 13:50 – 14:10 Marshall Horwitz (UWash), Restoring RUNX1 Levels in FPD/AML

  • 14:10 – 14:30 Alan Cantor (Boston Children’s), Pharmacologic Enhancement of Residual Wild Type RUNX1 Protein Activity in FPD/AML

  • 14:30 – 15:00 Coffee Break

Session 2. – Las Flores/El Presidente Rooms

  • 15:00 – 15:20 Stephen Nimer (University of Miami), Targeting Epigenetic Modifying Enzymes in FPD/AML

  • 15:20 – 15:40 Tim Ripperger (MH Hannover), RUNX1 Variants of Unknown Significance – Development and Application of Functional Assays

  • 15:40 – 16:00 Hamish Scott (Centre for Cancer Biology), Revertant Somatic Mosaicism – Natural Gene Therapy: Can We Make it Happen?

  • 16:00 – 16:10 Ashish Kumar (Cincinnati Children’s), Large FPD Family with Revertant RUNX1 Mutations

  • 18:00 Transport from the Four Seasons Hotel to dinner:  meet outside hotel lobby by 18:00

  • 18:15 – 20:45 Dinner at Monica and Tim Babich’s home

  • 20:45 Transport back to the Four Seasons

Tuesday, November 6 – Loggia Terrace

  • 6:45 – 7:45 Sunrise Ocean-View Guided Walk by a Santa Barbara Local

  • 8:00 – 9:00 Breakfast

Session 3. – Las Flores/El Presidente Rooms

  • 9:00 – 9:30 Benjamin Ebert (Dana Farber Cancer Institute), Clonal Hematopoiesis of Indeterminant Potential and Mechanisms of Increased Leukemia Risk

  • 9:30 – 10:00 James DeGregori (Univ. of Colorado Cancer Center), Context-dependent Selection in Oncogenesis

  • 10:00 – 10:30 Grover Bagby (Knight Cancer Institute), Inflammation Alters Clonal Selection Coefficients in Leukemogenesis

  • 10:30 – 11:00 Coffee

  • 11:00 – 11:30 Ulrich Steidl (Einstein College of Medicine), MDS to AML Progression at the Stem Cell Level

  • 11:30 – 12:00 Michael (Mick) Milsom (German Cancer Research Center), Stem Cell Attrition in Bone Marrow Failure and Aging

  • 12:00 – 12:30 Neal Young (NIH), Germline and Acquired Mutations in Aplastic Anemia

  • 12:30 – 13:30 Lunch – Palmera Garden

  • 14:30 Transport to Ganna Walska Lotusland Gardens – meet outside hotel lobby by 14:30

  • 15:00 – 17:00 Docent-led tour of Botanical Garden

  • 17:15 Transport to Dinner, Los Arroyos Mexican Restaurant on Coast Village Road. Walk back to hotel. Closing remarks, Tim Babich.


 
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RUNX1 PHILADELPHIA 2017
1ST ANNUAL SCIENTIFIC MEETING
PHILADELPHIA, PENNSYLVANIA NOV 13, 2017

Part of the 21st International RUNX ConferenceRUNX Transcription Factors in Development and Disease
November 12-15, 2017

Organizers: Nancy A. Speck, Ph.D. and Paul Liu, M.D., Ph.D.

Our first conference was held within the larger 21st International RUNX 2017 Conference at the University of Pennsylvania, in the historic city of Philadelphia.

The RUNX 2017 Conference was sponsored by generous donations from the Abramson Cancer Center at the University of Pennsylvania, Alex’s Lemonade Stand Foundation, the Leukemia & Lymphoma Society, the  and the Eunice and Irving Leopold Annual Scientific Symposium and Retreat, as well as ourselves, the RUNX1 Research Program. The editors of the book, “RUNX Proteins in Development and Cancer” have generously donated their royalties to help support the meeting.

The recipients of RRP’s two grant programs (in partnership with Alex’s Lemonade Foundation for Childhood Cancer and the Leukemia & Lymphoma Society) were featured in talks and breakout sessions on November 13th.