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Join us on our journey to end blood cancer.

We are the only foundation in the world that supports patients with RUNX1-FPD.

Join us on our journey to
end blood cancer.

We are the only foundation in the world that supports patients with RUNX1-FPD.

**What is RUNX1 Familial Platelet Disorder (RUNX1-FPD)?**

First identified in 1999, RUNX1-FPD (also known as RUNX1-FPDMM, FPD-AML, or FPDMM) is a rare inherited (germline) condition caused by a variant (mutation) in the RUNX1 gene. This genetic change can be passed from one generation to the next.

Autosomal Dominant Inheritance diagram. One parent with a RUNX1 variant and one parent without have four children. Two of the four children inherit the variant. — There is a 50% chance that each child will have the *RUNX1* mutation, regardless of whether they are male or female.

How it affects the body

Because the RUNX1 gene helps produce healthy blood cells, a variant that prevents it from working properly can lead to lower platelet counts and/or platelets that do not function as well as they should.

People with RUNX1-FPD may bruise easily, have frequent nosebleeds, or bleed longer than usual after injury or surgery.

It is important to understand that in certain circumstances, a traumatic injury can be life-threatening because of the bleeding caused by RUNX1-FPD.

Understanding blood cancer risk

The biggest concern for RUNX1-FPD patients and families is the high risk of developing blood cancer. Current estimates suggest the risk is between 35-50%. Importantly, the condition can vary greatly between families and even among family members.

Other possible health issues and diagnosis

People with RUNX1-FPD can also experience other health issues that are increasingly recognized as related to the disease, such as asthma, allergies, autoimmune disorders, or gastrointestinal problems.

New to RUNX1-FPD?

Whether you've recently received a diagnosis or learned that RUNX1-FPD runs in your family, find information about medical care, everyday life, and support.

Where to start on the Living with RUNX1-FPD page