Aging plays a critical role in how blood stem cells function and how the risk for conditions like clonal hematopoiesis and leukemia evolves. In this webinar, James DeGregori, PhD, shares his team's latest research on how aging reshapes hematopoietic stem cell fitness, including the role of RUNX1-related pathways and why certain mutations gain a selective advantage in this environment. These insights offer a deeper understanding of how leukemia risk develops, including in RUNX1-FPD.